Senior Associate Scientist – Downstream Process Development

We are looking for a Sr. Associate Scientist, Downstream Process Development, to provide support for execution of experiments designed to optimize recombinant adeno-associated virus (rAAV) downstream processing and purification for gene therapy applications. This role requires a desire to learn principles of chemical engineering, biochemistry and related disciplines, including chromatography, centrifugation and filtration.

Responsibilities and Accountabilities

  • Support process improvement activities and projects in collaboration with fellow scientists
  • Conduct experiments and analyses as part of a variety of research and development activities, e.g., small-scale studies, scale-up studies, technology transfer and process development
  • Actively participate as a member or multifunctional project teams
  • Evaluate and summarize the experimental results to improve understanding of downstream purification strategies, yield, purity and recovery
  • Support technology transfer internally and externally
  • Prepare and present data at internal group meetings

About you: 

  • BS degree in biology/biochemistry/chemistry/chemical engineering or equivalent with 1-3 years of experience in laboratory research required, preferably in recombinant protein/biomolecule purification development, technology transfer and/or bioprocess manufacturing
  • Experience in laboratory research and a desire to continue in a laboratory-focused role
  • Experience with filtration and chromatography
  • Familiarity with GLP and cGMP
  • Demonstrated ability to generate results and innovative solutions with minimum supervision
  • Good understanding of protein chemistry, protein analytics and bioprocess technology is required
  • Self-motivated, organized, capable of working independently, as well as in a collaborative/group environment to collaborate with manufacturing staff on experimental studies and GMP manufacturing
  • Experience with manufacturing of recombinant adeno-associated viral vectors is a plus
  • Experience with downstream process development specific to recombinant adeno-associated virus is a plus
  • Strong oral and written communication skills
  • Good judgment and innovation to achieve a solution within standard practices and procedures
  • Strong analytical and computer skills are required
  • Sound understanding of statistical experimental design and analysis, such as design of experiments, is a plus
  • Knowledge of Microsoft Office suite (Word, Outlook, Excel) required; experience with JMP a plus