Group Leader/Sr. Scientist

We are a gene therapy company changing lives with every genetic advancement.

Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that cure genetic diseases has never wavered.

As the only end-to-end gene therapy company in the industry, we’re built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.

We became a wholly owned, independently operated subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy Platform. Our global headquarters are in Research Triangle Park, North Carolina, a thriving biotechnology hub, and we maintain additional research and development operations in Scotland and France and gene therapy manufacturing in Spain.

We have an opportunity for a Group Leader/Senior Scientist to join the AskBio team in our Research Triangle Park, NC location and to be part of our continued success!

About the Role

Lead various aspects of upstream process development projects including design of experiments, set up, and execution to develop robust, efficient, scalable upstream process. Conduct experiments and analyses as well as provide guidance to team members as part of a variety of development activities, e.g., small-scale studies, scale up studies, technology transfer and process development. Collaborate with vendors and perform experimentation to develop and optimize media and feed formulations to increase cell density and yield. Participate in group discussions with fellow scientist and management team to discuss experimental strategies and operational issues related to experiments. Evaluate and summarize the experimental results, develop and test hypotheses to improve understanding of cell culture process, development strategies, yield and recovery. Support technology transfer to internal manufacturing team and other entities. Review process development and manufacturing documents (BPRs, SOPs, process development and investigation reports, etc.), supporting regulatory submissions when required. Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding. Will supervise a Scientist I and Research Associate III.

Will work in Research Triangle Park, NC


Must have a Master’s degree in biological or engineering discipline (Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent) or foreign equivalent, plus five (5) years of experience in the job offered or experience in laboratory research, preferably in recombinant protein/biomolecule cell culture/bioreactor development, technology transfer and/or bioprocess manufacturing.

Must have the following experience:

(1) In techniques used in cell culture processes for the production of biotherapeutics with at least one of the following: (1) process scale-up, (2) bioreactor operations, or (3) cell banking.

(2) Design, development, monitoring, and interpreting results to improve product quality, productivity and operation of cost effective, and scalable cell culture processes for biotherapeutic production.

(3) Leading technical team and supporting GMP technology transfers.

(4) Reviewing manufacturing processes, development and production data.

(5) Experience in working and leading cross functional teams and projects.

Candidates must possess work authorization for their intended country of employment.

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