Scientist, Gene Editing

About AskBio
Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at
Position Overview
We are seeking a highly motivated Scientist, Gene Editing to join our growing R&D team. The successful candidate will support our discovery efforts, as well as preclinical and clinical AAV gene therapy programs. The ideal candidate has in depth knowledge of CRISPR gene editing and gene modulation, DNA repair pathways, cell engineering, genomics platforms and recombinant AAV therapeutics. He/she can lead research teams and execute experimental studies that characterize and optimize therapeutic gene editing candidates through early development to first-in-human testing.
We are excited about our next Scientist, Gene Editing to join the AskBio team!

Job Responsibilities
The Scientist, Gene Editing will:
  • Lead and execute gene editing and gene therapy projects, and assays to support in vitro/in vivo proof of concept and safety outcomes.
  • Use relevant rodent or non-human primate models to test hypothesis and characterize gene editing/therapy candidates in development.
  • Lead and support internal and cross-functional research teams, to increase team capabilities and address strategic needs.
  • Lead and support collaborations with academic and/or industry partners to meet stage gated/milestone-driven goals for early therapeutic R&D programs.
  • Take initiative to identify and support emerging technical approaches and platforms that may drive increased value for pipeline programs.
  • Assist with the preparation and review of protocols, clinical study reports and translational medicine sections of plans, INDs, manuscripts, and technical reports.
  • Train or work closely with other lab-based personnel within R&D, translational medicine, and product development to ensure optimal laboratory environment (collaboration, culture, safety)
  • Demonstrate initiative, teamwork, collaboration, and technical expertise as an independent and team player.
  • Follow best practices for data integrity complying with organization and company standard operating procedures in a timely fashion.

Required Education & Experience

  • PhD in molecular biology, cell biology or related discipline with 6 years of experience in postdoc or industry setting.
  • Expertise in human/murine preclinical disease models and related experimental work.
  • Prior experience in a BSL2 or more environment.
  • Broad experience with gene editing modalities and techniques, including NGS methods for quantifying gene editing outcomes.
  • Experience with recombinant AAV vectors and viral delivery platforms, applying gene editing tools for cell engineering and genome-wide screens, cellular molecular imaging and hybridization techniques, and experience with statistical and genome analytical tools (GraphPad, R, SnapGene).

Preferred Skills & Experience

  • Ability to simultaneously support multiple programs and work in a fast-paced environment.
  • Innovative, self-motivated, and detail-oriented with good problem-solving ability.
  • Capable of working independently as well as a team contributor or team leader.
  • Must possess strong oral and written communication skills.