Careers in Gene Therapy

Let’s make history together

AskBio is a world-leading gene therapy company with unrivaled technology and a promising therapeutic pipeline, making us an exciting place full of promise, discovery and advancement. We are a fast-growing, patient-focused team that embraces collaboration, creative thinking and groundbreaking science to change lives.

Our headquarters are in Research Triangle Park, North Carolina, with European offices and facilities in Edinburgh, Scotland, and San Sebastián, Spain.

A benefits package worthy of our mission

We come to work each­­ day for a purpose greater than the job itself. For that reason, we offer employee benefits that reflect the importance of our work and the quality and skill of our people.

  • Collaborative and inclusive culture
  • Health, dental and vision insurance
  • 401(k) plan with company match
  • Health and dependent care flexible spending account
  • Life insurance
  • Short- and long-term disability insurance
  • 4 weeks of paid time off
  • 13 paid company holidays
  • 5 days annual sick leave
  • Business casual
  • Career advancement
  • On-site gym and beautiful walking paths
  • Collaborative and inclusive culture
  • Employer Pension Scheme
  • Life insurance
  • Critical Illness Cover
  • Private Healthcare
  • 30 days paid company holidays plus bank holidays
  • Bike to work scheme
  • Business casual
  • Career advancement
  • On-site gym and beautiful walking paths

Our Values

When you live an AskLife™, you join a team that embraces meaningful values to ensure our success.

Ask Life
Authoratative

Authoritative
We bring decades of experience in discovery and gene therapy development – from the bench to the bedside – that we want to share with the world.

Confident Icon

Confident
Driven by excellence and achievement, we have an unrivaled end-to-end gene therapy platform with foundational discoveries essential to the industry.

Boundless icon

Boundless
We are not afraid of the impossible and continuously innovate to make gene therapies accessible to all those in need.

Enthusiastic Icon

Enthusiastic
We love what we do and wake up every day motivated by a much larger purpose to change lives and erase genetic disease.

Responsible Icon

Responsible
We are humbled by the enormity of our mission and its meaning to families. We hold a relentless commitment to advance science and clinical outcomes.

Browse Open Positions

Please review the following open positions and apply now to upload your resume.

  • Research Associate III, Analytical Testing

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease, and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Research Associate III, Analytical Testing, reporting to the Analytical Development Biochemistry Group Lead, will support process development and non-GMP manufacturing teams through the execution of analytical assays.  This role will provide the execution and data analysis of analytical test methods to support continued manufacturing and process technology improvements and non-GMP rAAV vector release testing. Job Responsibilities  Execute on developed biochemical analytical assays related to ELISA, Potency Assays, HPLC-SEC, Capillary Electrophoresis, Mass Spec, residual assays. Provide analytical testing support for Process Development, R&D and external CMO teams when needed to assist in the development and analytical characterization of new therapeutic targets and manufacturing technology improvements. Participate in qualification/validation of developed analytical methods and tech transfer the methods internally and to partner CMO. Oversee support testing activities by coordinating incoming samples for testing, assay executions, data reviewing and reporting of the results. Ensure lab areas are clean and organized and equipment, supplies and raw materials are available for use. Contribute to technical discussions and investigations. Assist in making routine revisions to SOPs, Test Methods, study protocols and initiate new procedures as applicable. Required Education & Experience  BS or MS in Bioanalytical Chemistry, Biology, Biochemistry, Virology or related field with at least 1-2 years’ experience. Must possess skills in ELISA, Potency, cell based methods or other biochemistry techniques/applications. Preferred Skills Ability to multitask among multiple projects and teams and work independently in a fast-paced, highly interactive environment. Excellent interpersonal skills with the ability to interact effectively with people, internally and externally. Strong verbal and written communication skills. Must have an understanding of data analysis/interpretation. Good judgment and innovation to achieve a solution within standard practices and procedures.

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  • Laboratory Manager, Translational Medicine

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease, and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Laboratory Manager, Translational Medicine, reporting to the Sr. Director, Translational Medicine will be responsible for management of the day-to-day operational logistics of multiple laboratories within the Translational Medicine and Product Development departments. This position will also support laboratory quality and regulatory requirements for sample management and equipment. Job Responsibilities  Organize, implement, coordinate, enforce and/or monitor quality assurance programs. Ensure quality control and compliance procedures are followed and QC reports are up to date. Clinical sample management including receiving, sample tracking using GCP complaint software (LIMS). Order, receive, ship and track laboratory equipment and supplies in coordination with lab managers for other labs. Establish and maintain an inventory system for reagents, supplies and equipment. Track and perform equipment calibrations and preventative maintenance. Maintain equipment use binders and SOPs. Manage departmental budget. Coordinate waste management (red bag and waste streams). Perform lab tasks as needed, including but not limited to, equipment monitoring and calibration, reagent and media prep, processing and cryopreservation of primary cells/cell lines. Required Education & Experience  Bachelor’s degree. 5 years GxP experience and lab management in cell biology, immunology, molecular biology or related field. Preferred Skills Ability to handle multiple projects/teams simultaneously. Ability to work independently in a fast-paced, highly interactive environment with minimal supervision. Excellent verbal and written communication skills. Ability to build open and collaborative relationships and work effectively as a member of a multi-disciplinary team.

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  • Senior Director, Biostatistics, Clinical Development

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease, and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Senior Director, Biostatistics, Clinical Development, reporting to VP, Biostatistics, Clinical Development will provide technical leadership and operational oversight for the development of clinical strategies, the design, implementation and reporting of non-clinical, CMC, and clinical development programs and associated studies and clinical trials. This position will participate in close collaboration with the cross functional teams responsible for studies across all phases of drug development and will provide guidance and management to statisticians to ensure high quality and timely deliverables. In addition, this position will support regulatory interactions and serves as the statistical representative in the defense of the company position/approach on statistical issues and drug approvals globally. Job Responsibilities  Responsible for all deliverables related to statistical content. Provides guidance and management to statisticians, programmers, and data managers to ensure high quality and timely deliverables. Advise and influence senior leadership/functional leads on Biostatistics strategies and functional issues that have a business impact. Oversee biostatistics function in CRO’s; manage scope of work and relationships with other external statistician consultants. Manages resources, sets priorities, and ensures consistency and adherence to standards. Collaborates on protocol development including study design, endpoint selection, and power and sample size assessment. Responsible for SAP, data analysis and reporting (CSR). Supports DMC charter and meeting preparation. Represent the Company and Biostatistics function in interactions, both in writing and in person, with the FDA, EMA and other Health Authorities. Support regulatory submission and interaction, and IND/BLA filings and supports potential partnering requests. Become an integral member of cross-functional project teams, provides statistical input to a wide variety of scientific, clinical development and regulatory document types including Clinical Development Plans, protocols, synopses, Investigator Brochures, regulatory submissions and responses, and scientific publications and presentations. Develop solutions to statistical and data analysis issues for clinical, regulatory, and commercial teams. Communicates solutions cross-functionally. Contribute to creation/maintenance of, and provides training on statistical topics, and departmental SOPs and general standardization efforts. Maintain currency of new developments in

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  • Senior Talent Acquisition Partner

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease, and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. We have an opportunity for a Senior Talent Acquisition Partner to join the AskBio team and be part of our continued success! Position Overview The Senior Talent Acquisition Partner, reporting to the Director, Talent Management, is responsible for the recruitment of the company’s open requisitions while continuously improving recruitment processes to provide an excellent candidate experience to both active and passive candidates. To fill positions and build a talent pipeline, this role will need to maintain strong relationships with key business leaders, hiring managers, external vendors, and candidates. In addition to full-cycle recruitment, the role will also support talent management efforts including employer branding, community relations, university partnerships and an internship program. Job Responsibilities  Responsible for driving full-cycle recruitment of approved requisitions in partnership with hiring managers to include drafting/revising job descriptions, posting jobs, leading intake and debrief meetings, reviewing resumes, conducting initial HR interviews, scheduling interviews, preparing offer requests, making verbal offers and negotiating offer details until acceptance is received. Assure that job descriptions are updated and current, reflecting position responsibilities and required/preferred education, skills and experience for all positions being recruited. Partner effectively with People Operations to complete job leveling and compensation analysis of each position prior to working with the HR Coordinator to create the written offer documentation. Build a network of prospective academic and industry candidates for recurring scientific roles using direct sourcing (LinkedIn Recruiter), marketing campaigns, networking, and referrals. Encourage employees to be talent magnets and participate in the Employee Referral Program through the sharing job of postings using the approved content and graphics and referring known candidates to HR and the Company. Suggest interview strategy improvements and assist with the development of interviewer training materials and competency-based interviewing models focusing on candidate experience. Maintain relationships with the company’s preferred external recruitment agencies (retained and contingency), professional associations, community organizations, and university partners. Assist with the implementation of an Applicant Tracking System to automate the recruitment process including

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  • Research Associate II/III, Immunology

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Research Associate II/III, Immunology, reporting to the ImmunoAssay Group Lead, will be one of the key laboratory members who will have an opportunity to learn and contribute to the development of immunology cell or ligand-based assays in support of our gene therapy programs. This is an excellent opportunity for a candidate who is looking to build-up on his/ her experience in basic cell biology and immunology lab skills by being involved in planning and execution of pre-clinical studies and the assessment of clinical samples to advance the programs to clinical trials. We have an opportunity for a Research Associate II/III, Immunology to join the AskBio team in our Research Triangle Park (Durham), NC location and be part of our continued success! Responsibilities Execute immunogenicity assays, including cell-based or ligand based binding antibody, pharmacokinetic or biomarker assays under the guidance of a supervisor. Maintain a laboratory notebook or binder with worksheets recording details of performed experiments according to good documentation practices. Maintain inventories and/ or place orders of reagents and materials needed for the assigned projects for timely execution of related lab work. Perform data analysis and interpret the results accurately. Contribute to drafting the reports and presentations for technical discussions and/ or investigations with internal and external stakeholders. Required Education & Experience MS/ BS in Immunology, Biology, Biochemistry, Biotechnology, Virology or related field with 2-5 years of experience in industry or academia or combination of both. Possess foundational lab skills such as adhering to biosafety and chemical use guidelines (training provided) and making reagents at desired dilutions or concentrations. Demonstrated experience in the performing cell culture work and preforming analytical assays such as ELISA’s, MSD assays and western blots. Preferred Experience & Skills Experience with mammalian cell culture and processing/handling primary cells such as PBMCs. Knowledge of industry practices for the development, qualification/ validation of immunogenicity assays. Possess basic office skills using a PC and working with MS office tools (Word,

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  • Research Associate, Immunology

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Research Associate, Immunology, reporting to the Antibody Team Lead, will be one of the key laboratory members who will have an opportunity to learn and contribute to the development of immunology cell or ligand-based assays in support of our gene therapy programs. This is an excellent opportunity for a candidate who is looking to build-up on his/ her experience in basic cell and molecular biology and immunology lab skills by being involved in planning and execution of pre-clinical studies and the assessment of clinical samples supporting clinical programs. We have an opportunity for a Research Associate, Immunology to join the AskBio team in our Research Triangle Park (Durham), NC location and be part of our continued success! Responsibilities Execute immunogenicity assays, including cell-based or ligand based binding antibody, pharmacokinetic or biomarker assays under the guidance of a supervisor. Characterize transgene expression in cells using various molecular techniques including RNA/DNA extraction, qPCR/RT-qPCR and ELISA. Maintain a laboratory notebook or binder with worksheets recording details of performed experiments according to good documentation practices. Maintain inventories and/ or place orders of reagents and materials needed for the assigned projects for timely execution of related lab work. Perform data analysis and interpret the results accurately. Contribute to drafting the reports and presentations for technical discussions and/ or investigations with internal and external stakeholders. Required Education & Experience MS/ BS in Immunology, Biology, Biochemistry, Biotechnology, Virology or related field with 1-4 years of experience in industry or academia or combination of both. Possess foundational lab skills such as adhering to biosafety and chemical use guidelines (training provided) and making reagents at desired dilutions or concentrations. Demonstrated experience in the performing cell culture work and preforming analytical assays such as RNA/DNA extraction, qPCR/RT-qPCR, ELISA’s, MSD assays and western blots. Preferred Experience & Skills Experience with mammalian cell culture and processing/handling primary cells such as PBMCs. Knowledge of industry practices for the development, qualification/ validation of immunogenicity assays.

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  • Manager, HR Services and Operations

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Manager, HR Services and Operations oversees various HR Programs, processes, and policies with support from the Sr. Director, People Operations including immigration, leave of absence management, supporting overall employee experience, onboarding, managing and resolving employee and manager inquiries and content owner and management of the HR portal. We are excited about our next Manager, HR Services and Operations to join the AskBio team! Job Responsibilities Serve as first line employee resolution; own the employee relationship as the primary contact for all employee/customer inquiries concerning HR-related programs, policies, and tools; provide consistent and accurate responses with escalation, as necessary. Responsible for the HR-related inquiries and escalations including managing and responding to inquiries regardless of entry point from managers and employees. Vendor management of the outsourced benefits call center and other vendors. Oversees various HR programs including, but not limited to: Immigration program including working directly with third parties. Leave of absence management working directly with outsourced management team and benefits broker. Employee experience and onboarding in partnership with Director of Talent Management. Content management of the HR portal. Supports annual processes including open enrollment and year-end performance and compensation cycle. Interprets various routine HR plans, programs, policies and procedures for employees and managers and provides advice and recommendations to the business. Coordinates with third party providers, internal stakeholders, and internal and external counsel. Proactively provide suggestions or act on process improvements and automation. Identifies trends to work with other HR team members in developing FAQs, updating employee communication vehicles. Promotes the use of employee and manager self-service via systems and tools and assists employees and managers in accessing and using these systems. Ability to access the various systems/tools used to provide HR support. Generates thoughtful metrics and reports for HR and management as requested. Examples may include headcount reports, audit request special projects, benefit enrollment and deduction reports. Identify and document enhancements to HR Operations and workflows. Identify trends and provide solutions

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  • Director, Data Management

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Director, Data Management provides oversight of all data management activities outsourced to external suppliers and/or conducted in house, including but not limited to database design specification development, database design programming, database User Acceptance Testing (UAT) and database deployment to research sites thereby ensuring the quality and integrity of all databases used in AskBio sponsored trials. We are excited about our next Director, Data Management to join the AskBio team! Job Responsibilities The Director, Data Management will: Provide oversight of all data management activities outsourced to external suppliers and/or conducted in house, including but not limited to database specification development, database design programming, database User Acceptance Testing (UAT) and database deployment to research sites. Effectively manage changes to database design and data management requirements as necessary due to protocol amendments and changes to overall clinical development programs. Support the development and implementation of innovative strategies and technologies for data management database programming ensuring capture and validation of all required trial data. Integrate technology seamlessly to allow for data re-use and operational efficiencies in both data management and statistics Provide technical guidance to DM staff and vendors around standards, practices, and specifications to ensure integrated data processing and computing solutions. Develop, troubleshoot, and maintain complex programs and utilities leading to database design, creation, validation, & use as well as clinical trial statistical analysis. Draw on experience with identification of challenges, inefficiencies or downstream impacts, identifying solutions, engagement of appropriate stakeholders, garnering of management support, and implementation of a roll out plan (i.e., procedural documents, training materials, and training) to minimize risk and maximize quality. Identify opportunities for increased efficiency and consistency and provides leadership and support to improvement initiatives. Delivers expertise to development teams with regard to driving standardization and formulating solutions to complex issues. Serve in a leadership role on cross-functional initiatives and capital projects providing business input into system/user requirements, risk assessments, process document authoring, validation script writing, execution, and approval,

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  • Manager, Clinical Supplies

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Manager, Clinical Supplies provides strategic oversight of the end-to-end supply chain for assigned gene therapy investigational assets, including provision of placebo supplies, as needed, based on study design and implements supply strategies to deliver investigational medicines to patients. This role is responsible for influencing clinical plans relative to investigational product (IP) supply and optimizing supply strategies, so they are patient-focused, risk-adjusted, and cost effective. Furthermore, the CSM follows through on supply chain performance to ensure successful execution of the supply chain, with a focus on quality. This role involves oversight of AskBio sponsored clinical studies (all phases). We are excited about our next Manager, Clinical Supplies to join the AskBio team! Job Responsibilities The Manager, Clinical Supplies will: Lead the cross-functional Clinical Supply Chain team and is accountable for the Clinical Supply Workstream as part of the overarching development process. Build and maintain strong working relationships with Clinical and cross-functional program teams, including serving as the first point of escalation for issues related to clinical product supply. Challenge key assumptions and Clinical planning parameters while influencing clinical study proposals to ensure efficient cost/risk/ benefit trade-offs. Contribute to study specific Pharmacy Manuals as necessary to support study start and execution. Develop and supervises long-term demand and supply plans for all assigned AskBio assets. Design and executes supply chain strategies that ensure consistent timely delivery of IP with minimal waste. Work with business partners to oversee the effective execution of supply chain plans while proactively identifying potential obstacles to success and taking action to resolve issues. Develop costed, risk-based scenarios for supplies to enable the Clinical Development Team(s) to make informed decisions regarding budget allocation. Ensure supply chain planning is aligned with key project milestones Create, lead, influence and work with cross-functional teams, including third-party groups, to co-ordinate and handle the delivery of clinical supplies for specified AskBio asset(s). Creates Study Specific Clinical Supply Plans (or equivalent) for specified projects. Accountable for problem-solving and

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  • Associate Director, Clinical Operations

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Associate Director, Clinical Operations will provide management and oversight of AskBio’s pipeline studies. The incumbent will be responsible for aspects of study conduct and CRO oversight and will be a key point of contact for clinical study project management, communications, and daily operations for AskBio sponsored clinical trials. Experience and knowledge of end-to-end management of clinical trial conduct, knowledge of the pharmaceutical industry and an understanding of clinical drug development, clinical trials operations and FDA/ICH regulatory requirements are essential. The ideal candidate should be willing to travel approximately 10-15% of the time. We are excited about our next Associate Director, Clinical Operations to join the AskBio team! Job Responsibilities The Associate Director, Clinical Operations will: Ability to manage and collaborate on complex protocols within a matrix environment (Data Management, Safety, budget oversight, outsourcing and vendor alliance management). Critical thinking skills for problem solving with strategic thinking capacity to drive the study(ies) and to understand the upstream, downstream and lateral implications of decisions that affect study outcomes and timelines. Identify opportunities for increased efficiency and consistency and provides leadership and support to improvement initiatives. Deliver expertise to Clinical Operations teams to drive standardization and formulating solutions to complex issues Work with project/program head(s) to define and develop clinical trial objectives and milestones;  manages and reports comprehensive study timelines and metrics; management/oversight of external vendor deliverable reports and budgets. Report on all aspects of the study progress to Operations management and as necessary to other and more senior levels across the business. Effective, consistent & regular tracking of project(s). Core member of Project Teams and works with project manager to develop trial plans and budgets; collaborates within Clinical Operations and with other departments on study budget management and vendor and site payments; oversees delivery of clinical studies to agreed milestones and budgets. Collaborate with the following groups across the trial program such as: Data Management, Statistics, Clinical Supplies, Safety, etc. to identify and mitigate

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  • Senior Clinical Trial Associate

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Senior Clinical Trial Associate provides support for the creation and maintenance of paper and/or electronic clinical trial records including the Trial Master File with a focus on maintaining inspection readiness throughout the lifecycle of an individual clinical trial or a clinical development program. The Senior Clinical Trial Associate is an integral part of the study/trial team in assuring that all clinical trial paperwork is handled appropriately and that assigned TMFs are complete, accurate, and timely. We are excited about our next Senior Clinical Trial Associate to join the AskBio team! Job Responsibilities The Senior Clinical Trial Associate will: Support the clinical trial manager(s) and overall study team for all phases of study conduct (feasibility, planning and start up, conduct/maintenance, and closeout). Assist with maintaining study status updates on agreed cadence (examples of activities tracked include IRB approvals, regulatory document collection, patient enrollment, monitoring status). Provide support for inspection readiness by formatting, proofreading documents and contributing to the establishment, maintenance and quality control of the Trial Master File (maintained internally or by CROs). Assist clinical trial managers with preparation, handling, distribution and tracking of clinical trial supplies and other study supplies. Prepare and maintains investigator information tracker for clinical trial operations, working with in house or vendor staff. Support compilation of documentation for CSR appendices based on clinical trial protocol and clinical study report (CSR) requirements. Assist in the development of the structure of Trial Master File and filing system and supports study team in maintaining up to date study documents; assists with or independently conducts Quality Control review of in house or vendor Trial Master File(s). Coordinate timely resolution of document issues with the documents from study sites, data management centers, and other trial collaborators. Generate regulatory compliant Certified Copies when/as needed. Create Metrics Reports to assist with trial oversight and to demonstrate quality and completeness of the TMF as well as other study documents. Assist with planning, organization and conduct of

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  • Director, Medical Writing

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Director, Medical Writing (MW) will be responsible for the overall scientific leadership providing clinical direction to team members, developing and writing content for their specific projects as well as reviewing scientific content created outside AskBio. This position will have direct interaction with leading key opinion leaders. The Medical Writer is required to travel to project specific advisory board meetings, and at times, may be required to attend scientific congresses. Projects may include development of clinical content which includes case studies, text based and power point slides. Must be knowledgeable on the appropriate guidelines including, but not limited, to the ACCME Standards for Commercial Support, PhRMA Code, and OIG Guidance. The Director, Medical Writing (MW) is also responsible for the efficient preparation of high-quality, strategically aligned medical writing deliverables that support the clinical development, safety, and regulatory requirements of a clinical program. This position requires an advanced knowledge of BLA/MAA submissions and working knowledge of and experience in document management systems. We are excited about our next Director, Medical Writing to join the AskBio team! Job Responsibilities The Director, Medical Writing will: Align, coordinate, and build consistent information and messages across all individual documents within a clinical program, starting with initial strategic plans, continuing through study level documents to final program level deliverables (i.e., regulatory submission or publication of key journal articles for a publication plan). Analyze proposed plans, programs, individual studies, and related documents for their ability to deliver the information required by the target audience (i.e., regulatory authority) in a compelling fashion with accuracy and consistency. Develops clear, concise outlines, on-target first drafts, and proactively incorporates data/revisions Possess and utilize strong meeting planning & facilitation skills to convene document review roundtable meetings to gather, collate, and update and finalize draft documents to include pertinent information; in the absence of meetings, efficiently uses technology to circulate and finalize documents Determine resource needs, proactively identifies issues and solutions, and sets timelines and

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  • Scientist, Gene Editing

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We are seeking a highly motivated Scientist, Gene Editing to join our growing R&D team. The successful candidate will support our discovery efforts, as well as preclinical and clinical AAV gene therapy programs. The ideal candidate has in depth knowledge of CRISPR gene editing and gene modulation, DNA repair pathways, cell engineering, genomics platforms and recombinant AAV therapeutics. He/she can lead research teams and execute experimental studies that characterize and optimize therapeutic gene editing candidates through early development to first-in-human testing. We are excited about our next Scientist, Gene Editing to join the AskBio team! Job Responsibilities The Scientist, Gene Editing will: Lead and execute gene editing and gene therapy projects, and assays to support in vitro/in vivo proof of concept and safety outcomes. Use relevant rodent or non-human primate models to test hypothesis and characterize gene editing/therapy candidates in development. Lead and support internal and cross-functional research teams, to increase team capabilities and address strategic needs. Lead and support collaborations with academic and/or industry partners to meet stage gated/milestone-driven goals for early therapeutic R&D programs. Take initiative to identify and support emerging technical approaches and platforms that may drive increased value for pipeline programs. Assist with the preparation and review of protocols, clinical study reports and translational medicine sections of plans, INDs, manuscripts, and technical reports. Train or work closely with other lab-based personnel within R&D, translational medicine, and product development to ensure optimal laboratory environment (collaboration, culture, safety) Demonstrate initiative, teamwork, collaboration, and technical expertise as an independent and team player. Follow best practices for data integrity complying with organization and company standard operating procedures in a timely fashion. Required Education & Experience PhD in molecular biology, cell biology or related discipline with 6 years of experience in postdoc or industry setting. Expertise in human/murine preclinical disease models and related experimental work. Prior experience in a BSL2 or more environment. Broad experience with gene editing modalities and techniques, including NGS

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  • Director, Alliance Management

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Director, Alliance Management will lead the alliance management function and be a key member of the business development team. The role calls for a proven team player who brings an exceptional analytical rigor, keen attention to detail, and strong time-management and communications skills to alliance management. Reporting to the General Counsel, the Director will be responsible for ensuring that day-to-day operating requirements for strategic alliances are effectively managed. Alliance management function lives at the interface of the science, medicine, business, and law; candidates will be expected to show strong capabilities across those disciplines. Direct responsibilities will include developing and managing relationships with all individuals involved in the strategic alliance, planning and coordinating governance activities with the alliance partner, resolving alliance issues that may arise, providing relevant reports and feedback to management.  The Director will be responsible for management of academic engagements, including Sponsored Research Agreements (SRAs) and Material Transfer Agreements (MTAs) as well as intercompany and academic licenses. The Director will collaborate with stakeholders in many different functions to ensure alignment, and completion of key tasks in a nimble and fast-moving environment. We are excited about our next to Director, Alliance Management join the AskBio team! Job Responsibilities Input into deal structure as it relates to ongoing obligations for an alliance. Implement successful alliance launch for new alliances and a relevant operational model. Escalate operational-level conflicts. Maintain organizational alignment. Manage alliance performance per alliance metrics/measurement system. Plan, coordinate, and monitor operational activities of alliance in conjunction with internal teams. Establish and maintain relationships within and across organizations. Coordinate interactions/steering committees with alliance partner by developing agenda, setting priorities for discussions, capturing meeting minutes and tracking/following up on actions. Required Education & Experience Bachelor’s degree from an accredited university. Minimum 3 years of university, pharma or biotech experience. Preferred Skills & Experience MBA or science related graduate degree. Experience working in research collaborations or with external partners. Experience managing people/teams. Knowledge of

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  • Bioanalytical and Bioassay Lead

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We are seeking 2 experienced and highly motivated Bioanalytical and Bioassay Leads to join our Bioanalytical and Bioassay group located at Research Triangle Park, Durham NC. Reporting to the Sr. Director, the Bioanalysis and Bioassay Lead is expected to lead the bioanalytical and bioassay development and drive technical excellence within the team. We are excited about our next Bioanalysis and Bioassay Lead to join the AskBio team! Job Responsibilities The Bioanalysis and Bioassay Lead will: Serve as a SME and/or lead scientist, lead and manage the internal and external bioanalytical and bioassay assay design, development, troubleshooting, transferring, and sample testing and reporting to support preclinical and clinical gene therapy program development. Independently develop, optimize, and troubleshoot Cell-based assays as well as other plate-based assays using variety of platforms including colorimetric/luminescent/fluorescent ELISA, MSD, and high-content imaging in support of developing release and characterization assays for gene therapy products. Independently develop, optimize, and troubleshoot molecular biology/biochemistry assays, such as ELISAs, MSD, enzyme activity assay, qPCR/ddPCR to meet the bioanalytical need for various AAV gene therapy programs. Prepare/scientific review of analytical data and methods, protocols, and reports generated by internal and external laboratories. Participate and present in departmental and cross-functional project team meetings. Author and review relevant sections of regulatory submissions support the IND/CTA and BLA/MAA submissions. Manage CRO relationships for assay validation and qualification. Stay current with the latest bioanalytical and bioassay methods and technologies, current regulatory regulation and guidance, and industry’s best practices. Required Education & Experience Ph.D. in Biology, Biochemistry, molecular biology, Cell Biology, or a related field with minimum 6+ years of relevant experience and a strong publication record in peer reviewed journals or Master with 12+ years of directly related industry experience. Experience and expertise in virus-related research including cell culture, virus transduction, cell line development, and characterization. Highly experienced in experiment designing, executing, and troubleshooting for qPCR/RT-qPCR, ddPCR/RT-ddPCR, ELISA, MSD, cell-based assay, and ligand-based assays FACS, or other novel platforms. Previous supervisory experience in bioanalytical or cell-based

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  • Research Associate, Bioanalytical and Bioassay

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We are seeking 2 highly motivated Research Associate, Bioanalytical and Bioassay to join our Bioanalytical and Bioassay group located at Research Triangle Park, Durham NC. Reporting to the Sr. Director, the Research Associate is expected to assistant the bioanalytical and bioassay development and contribute to the technical excellence within the team. We are excited about our next Research Associate, Bioanalytical and Bioassay to join the AskBio team! The Research Associate, Bioanalytical and Bioassay will: Assist in the execution of bioanalytical and bioassay methods development, optimization, sample testing and reporting. Perform routine molecular biology/biochemical assays/cell-based assay, such as western blotting, capillary electrophoresis, ELISAs, MSD, enzyme activity assay, and qPCR/ddPCR to support various studies. Document experimental results in electronic laboratory notebook and drafts technical reports. Help QC and review of analytical data and methods, protocols, and reports. General laboratory maintenance including reagents, inventory preparation and maintenance. Ensure timely completion and compliance with GxP and all company training requirements. Required Education & Experience MS degree with 1-3 years of experience, or a BS/BA degree with 3 or more years of experience in Biology, Biochemistry, Biotechnology, molecular biology, or related field. Demonstrated experience with mammalian cell culture and maintenance. Preferred Skills & Experience Previous experience in performing ELISA, Meso Scale Diagnostic, qPCR/ddPCR. Knowledge/experience of GxP industry practices for the development, qualification/validation of bioanalytical method and potency assay. Self-motivated, detailed, and organized individual with excellent interpersonal skills and strong oral and written communication skills to interact effectively with people, internally and externally.

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  • Scientist, Immunology (Flow Cytometry/Biomarker)

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Scientist, Immunology (Flow Cytometry/Biomarker) is one of the key laboratory members who will have an opportunity to learn and contribute to the understanding of AAV Immunogenicity by performing immunological assays in support of our gene therapy programs. This is an excellent opportunity for a candidate who is looking to build-up on his/her experience in Cell Biology and Immunology lab skills by being involved in the assessment of clinical samples and drive exploratory data analyses of clinical studies to advance programs to clinical trial stages. We are excited about our next Scientist, Immunology (Flow Cytometry/Biomarker) to join the AskBio team! Responsibilities Perform data analysis and interpret the results accurately and timely. Execute flow cytometry and/or biomarker assays under the guidance of supervisor. Maintain a laboratory notebook or binder with worksheets recording details of performed experiments. Assist in the maintenance of inventories and/or place orders of reagents and materials needed for the assigned projects for timely execution of related lab work. Contribute to drafting the reports and presentations for technical discussions and/ or investigations with internal and external stakeholders. Required Education & Experience MS/ PhD in Immunology, Biology, Bioinformatics, Biochemistry, Biotechnology, Virology, or related field with 2-6 years of experience in industry, academia, or combination of both. Experience with multicolor flow cytometry, performing multiplexed analytical assays such as Meso Scale Diagnostics or Luminex, and/or high-dimensional analyses of deep-data such as transcriptomics, proteomics, or metabolomics. Preferred Experience & Skills Prior Experience with electronic lab notebooks, statistical software such as Graphpad or JMP, and proficiency with flow cytometric analysis software such as FCS Express or FlowJo. Expertise in managing, curating, and analyzing large datasets accumulated via multiplexed, multicolor (>12), and/ or deep-data platforms (e.g. NGS or proteomics). Demonstrated experience with mammalian cell culture and processing/handling primary cells such as PBMCs. Possess basic office skills using a PC and working with MS office tools. Ability to write software scripts, e.g. R or Python experience, or bioinformatics training. Self-motivated, organized, capable

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  • Director, Business Development

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Director, Business Development is an engaged, experienced, and inspirational biopharmaceutical industry professional who will help position the Company as a leader in the emerging field of gene therapy. Reporting to the General Counsel, and in partnership with the Executive Team, the Director, Business Development will play a lead role in developing and executing the near term and long-range strategy for the Company at the interface of science, medicine, and business. Direct responsibilities will include business development strategy and execution, including licenses, collaborations and acquisitions. Keen insights in these areas will help the Company position existing programs in this rapidly evolving gene therapy market and identify opportunities to expand its pipeline and product portfolio. The Director, Business Development will bring cross-functional leadership and collaboration to ensure alignment, ideation, and implementation, working closely with the Company executive leadership team, in a nimble and fast-moving environment. Demonstrating leadership as it relates to the Company’s culture and values are paramount for this role. He/she will also serve as a leader with external constituents including thought leaders, partners, and as a general representative of the Company. We are excited about our next Director, Business Development to join the AskBio team! Job Responsibilities Lead the development, implementation, and execution of overall company business development strategy focused on optimizing key value drivers across the organization while fully complimenting corporate strategy set by CEO. Lead the development, implementation, and execution of overall company business development strategy focused on optimizing key value drivers across the organization while fully complimenting corporate strategy set by CEO. Lead sourcing, due diligence, negotiations and execution of licenses, collaborations, sponsored research and acquisitions or divestitures. Lead global, cross-functional team on a project-by-project basis. Serve as a role model in establishing a collaborative spirit within the BD organization. As the Company continues to evolve, play a leadership role in supporting cultural transitions associated with product development and pipeline strategies in early clinical research through clinical developments stages, while maintaining a strong

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  • Manager, Business Development

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Manager will be a key member of the business development team. The role calls for a proven team player who brings an exceptional analytical rigor, keen attention to detail, and strong time-management skills to strategy and business development projects. Reporting to the General Counsel, the Manager will play a key role in leading and advancing projects that will develop near-term and long-range strategy for the Company. The business development function lives at the interface of the science, medicine, business, and law; candidates will be expected to show strong capabilities across those disciplines. Direct responsibilities will include search and evaluation, corporate strategy development projects, competitive intelligence, supporting due diligence, supporting business development transactions, and financing activities. The Manager will collaborate with stakeholders in many different functions to ensure alignment, and completion of key tasks in a nimble and fast-moving environment. We are excited about our next Manager, Business Development to join the AskBio team! Responsibilities Support business development transactions. Proactively search for and scientifically evaluate external growth opportunities, provide robust and comprehensive assessments of these opportunities. Conducting scientific diligence to assess scientific plausibility, strategic fit and delivering critical path viewpoints on value proposition and rationale of potential opportunities. Asses emerging business-development opportunities by working in collaboration with research, clinical and business development colleagues across AskBio with a primary focus on the scientific and technical merit to advance (or exclude) opportunities for further consideration. Drive competitive intelligence, as it relates to the AAV gene therapy marketplace, to shape and inform the current and future Research & Development strategy. Conduct future life sciences market assessments based on the collection of data about relevant published research, regulatory filings and notices, public policy and regulatory developments. Present and debate business rationale, analyses and proposals with the senior members of the Business Development team; interface with senior management to reach decisions. Required Experience Minimum 3 years of pharma or biotech experience including research and clinical translation, with at least 2

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  • Associate Director, Program Manager

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. We are excited about our next Associate Director, Program Manager to join the AskBio team! Position Overview The Associate Director, Program Management will: Create and maintain the overall development plans and timelines for the drug development programs assigned. Partner with Program Lead to provide leadership, direction, and execution of all Program Management procedures and activities from pre-clinical through product launch. Provide operational management to the program team, including facilitating issue identification and resolution, problem-solving, and contingency planning. Define the program’s scope and objectives, and effectively coordinate the activities of the cross-functional team to meet the objectives. Collaborate with the program team to develop and communicate program updates to key stakeholders and leadership team. Job Responsibilities Operations Management and Leadership Co-lead cross-functional activities and communications involving team members to ensure deliverables related to the program are on track. Identify issues and develop appropriate risk mitigation plans. Update key stakeholders and leadership in a timely manner of program status, key achievements, risks/mitigation, scope deviations. Program Timeline, Resource, and Cost Management Ensure alignment with cross-functional leaders to allocate appropriate resources in support of program timelines and objectives. Work with the program team to develop and maintain an integrated program development plan that accurately captures timelines, resource plans, risk mitigation strategies, regulatory plans, and budget. Program Information/Communication Management Work with Program lead and corporate communications to develop and execute a publication and communication plan. Ensure program documentation is updated and easily accessible to all the program team and leadership. Ensure timely documentation of team meetings, key decisions, and action items with clear communication to matrixed teams on expectations. Required Education & Experience B.S./M.S in a related field. 5-10 years minimum pharmaceutical/biotechnology experience with minimum of 3-5 years of in program management, late development PM experience. Preferred Skills & Experience CNS experience. Excellent program management skills including budget and resource management. Ability to manage programs and work with team members in a matrixed environment. Detail-oriented with strong organizational skills.

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  • Project Engineer

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We have an opportunity for a Project Engineer to join the AskBio team in our Research Triangle Park (Durham), NC location and be part of our continued success! The Project Engineer will assist in the management of capital projects and day-to-day operation of AskBio facilities. Responsibilities Assist in the development and delivery of projects, conducting project team meetings and recording all minutes. Participate in raising issues and engage in conflict resolution during programming, construction, commissioning, and project closeout of assigned projects. Support the implementation of all key project processes and tools to support project delivery and monitor progress, providing updates and recommendations to the internal engineering team. Participate in the review and assessment of proposed variations/scope changes and identify the impact of cost and schedule to the project. Attend and monitor meetings, escalating issues that may arise to appropriate stakeholders. Coordinate with the stakeholders, client team, design team and contractors on all interactions required for Project Delivery. Assist with document control for construction and facility projects utilizing MS SharePoint and DSI asset management software packages. Work with engineering and lab teams to maintain accuracy within the DSI asset management system with timely updates. Assist with Rees Scientific lab monitoring system and troubleshoot/diagnose minor equipment problems. Work with engineering team to implement safety initiatives to ensure site compliance. Assist with equipment and lab setup. Required Education & Experience Bachelor’s degree from accredited college/university. 5-10 years’ experience working in a Project Engineering/Management role. Prior pharma, laboratory, or facilities experience. Preferred Experience & Skills Possess basic office skills using a PC and working with MS office tools (Word, Excel and PowerPoint). Self-motivated, organized, individual capable of working independently as well as a team contributor. Strong verbal and written communication skills. Excellent interpersonal skills with the ability to interact effectively with teams, internally and externally.

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  • Facilities Lab Technician

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We have an opportunity for Facilities Lab Technician to join the AskBio team in our Research Triangle Park (Durham), NC location and be part of our continued success! Responsibilities Maintain recycling vendor service schedule and assist lab teams with organization of material to be recycled. When serviced by vendor, record recycling haul-off documentation. Ensure each lab has proper trash and recycling receptacles to maintain compliance. Assist with PPE station upkeep and stocking. Assist with manufacturing consumable pick up for off-site storage. Assist lab waste vendor(s) on pickup days and keep tabs on supply of biohazard boxes and liquid waste receptacles, maintaining a steady supply for lab operations. Daily duties shall include the removal of lab waste to the common waste storage room for weekly vendor pickup. Assist with vendor scheduling, coordination, and visits. Assist EHS with safety initiatives and posting safety starters bi-weekly. Organize and maintain parts washer and autoclave area and wash parts, as necessary. Required Experience 5 years’ experience working in a commercial facility. Preferred Experience & Skills Prior pharma, laboratory, or facilities experience. Possess basic office skills using a PC and working with MS office tools (Word, Excel and PowerPoint). Self-motivated, organized, individual capable of working independently as well as a team contributor. Excellent interpersonal skills with the ability to interact effectively with teams, internally and externally.

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  • Research Associate, Immunology (Cell-based Assays)

    We have an opportunity for a Research Associate II/III, Cellular Immunology to join the AskBio team in our Research Triangle Park (Durham), NC location

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  • Scientist II

    We have an opportunity for a Scientist II to join the AskBio team in our Research Triangle Park, NC location.

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  • Research Associate, Immunology

    The Research Associate II/III, Immunology at AskBio will be one of the key laboratory members who will have an opportunity to learn and contribute to the development of immunology cell or ligand-based assays in support of our gene therapy programs.

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  • Project Manager, Operations

    We are seeking a highly motivated scientist to join our growing Program Management team. The selected individual will play an important role in supporting AskBio’s programs.

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  • Scientist I/II, Gene Editing

    We are seeking a highly motivated scientist to join our growing R&D team. The successful candidate will support our preclinical in vivo gene editing programs in Research and Development.

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  • Clinical Development Medical Director

    This role is responsible for one or more clinical programs across indications, involving one or multiple molecular entities.

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  • Non-Clinical Manufacturing/Process Development Lab Manager

    This role is responsible for laboratory operations and supports quality and regulatory requirements for sample management and equipment.

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  • Associate Director – Clinical Trial Manager

    This role will provide oversight of AskBio’s pipeline studies, including study conduct and CRO oversight and will be a key point of contact for study project management, communications, and daily operations for clinical INDs.

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Equal Opportunity Employer

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements.

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