Careers in Gene Therapy

Let’s make history together

AskBio is a world-leading gene therapy company with unrivaled technology and a promising therapeutic pipeline, making us an exciting place full of promise, discovery and advancement. We are a fast-growing, patient-focused team that embraces collaboration, creative thinking and groundbreaking science to change lives.

Our headquarters are in Research Triangle Park, North Carolina, with European offices and facilities in Edinburgh, Scotland, and San Sebastián, Spain.

A benefits package worthy of our mission

We come to work each­­ day for a purpose greater than the job itself. For that reason, we offer employee benefits that reflect the importance of our work and the quality and skill of our people.

  • Collaborative and inclusive culture
  • Health, dental and vision insurance
  • Competitive salaries
  • Bonus eligibility for all
  • Long-term incentive eligibility for all
  • Retirement plans 
    • 401(k) retirement plan with generous match in the US
    • Employer Pension Scheme in the UK
  • U.S. Benefits
    • Two medical plan options
    • Health and flexible savings accounts
    • Dental and vision insurance coverage
    • Life & Disability coverage
    • TeleMedicine
    • Employee Assistance Program
    • Generous paid time off
    • Extended paid maternity leave
    • Extended paid parental leave
    • December holiday shutdown
    • Domestic partner benefits
  • U.K. Benefits
    • Life insurance
    • Critical Illness Cover
    • Private Healthcare
    • Generous paid time off
    • Bike to work scheme
    • December holiday shutdown
  • Casual dress
  • Free refreshments and snacks in our offices
  • Employee recognition program
  • Collaborative and inclusive culture
  • Flexible work options

Our Principles

These are the three principles that AskBio is built on:

  1. Advance innovative science by pushing boundaries.
  2. Bring transformative therapeutics to patients in need. 
  3. Provide an environment for employees to reach their fullest potential.

Living Our Values

Vision

Pioneering science to create transformative molecular medicines.

Mission

Lead innovative science and drive clinical outcomes to transform people’s lives.

Be a Pioneer

We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

Confident Icon

Cultivate Collaboration

Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

Enthusiastic Icon

Embrace Responsibility

We are humbled by the enormity of our mission.  We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

Responsible Icon

Raise the Bar

Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

Act with Uncompromising Integrity

Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Authoratative

Browse Open Positions

Please review the following open positions and apply now to upload your resume.

  • Manager, Quality Assurance

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need.  Provide an environment for employees to reach their fullest potential.  Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. We have an opportunity for a Manager, Quality Assurance to join the AskBio team and be part of our continued success! Position Overview The Manager, Quality Assurance, reporting to the Director, GMP Quality Assurance, will be responsible for assisting in the management of AskBio’s Quality Management System (QMS) and will strongly support AskBio’s Culture of Quality. This role will assure corporate compliance with applicable GMP national, international, and state regulations.  This position will be based at AskBio’s headquarters facility in RTP, NC with 15% domestic travel expected. Responsibilities Assist in the development, implementation, and integration of AskBio’s QMS and AskBio’s Culture of Quality. Provide quality reviews of various records including, but not limited to Change Controls; SOPs; analytical methods, protocols, and summary reports; equipment and computer system qualification and validation plans, protocols, and summary reports; batch records; QC data; primary and secondary packaging; labels; deviations, non-conformities, Corrective Action/Preventive Action (CAPAs). Develop key metrics reporting to drive continuous improvement in compliance. Recruit, manage, develop, and mentor QA Specialist(s). Assist in the qualification and oversight of vendors, contract manufacturers, contract

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  • Specialist, Quality Assurance

    The Specialist, Quality Assurance, reporting the Quality Assurance Manager, will be responsible to support the on-going enhancement of AskBio’s Quality Management System (QMS) by performing Quality Assurance activities related to current Good Manufacturing Practice (cGMP) in collaboration with cross-functional teams with adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs), as appropriate. This position will be based at AskBio’s headquarters facility in RTP, NC with 15% domestic travel possible.

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  • Research Associate I, Gene Editing

    The Research Associate I, Gene Editing, reporting to the Scientist II, Therapeutic Gene Editing Platforms, will help us develop and discover next-generation gene therapies utilizing, state-of-the-art AAV and gene editing technologies. This position will conduct experiments to support our Gene Editing pre-clinical development program as part of the R&D department. The ideal candidate will have direct experience with quantitative molecular biology techniques, including plasmid cloning, isolation of DNA, RNA, and protein from cells and tissues, quantitative PCR, RT-PCR, ELISA, SDS-PAGE, and Western Blot. The candidate should have a clear understanding of AAV mediated gene therapy and gene editing technologies, including CRISPR; however, prior research experience in these technologies is not required. The position is based at AskBio’s RTP, NC Headquarters Facility.

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  • Associate Director, Liver Disease Program – Gene Editing

    The Associate Director, Liver Disease Program – Gene Editing, reporting to the Vice President, R&D Gene Editing, will lead our discovery efforts and preclinical AAV gene editing programs in rare liver disease. The ideal candidate will lead our in vivo liver disease gene editing programs, progressing optimized candidates through early development towards first-in-human studies and will also lead a team of scientists that generates key data for establishing proof-of-principle, efficacy, and safety data. The position is based at AskBio’s RTP, NC Headquarters Facility.

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  • Scientist II, Nanoplatform Discovery R&D

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need.  Provide an environment for employees to reach their fullest potential.  Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. We have an opportunity for a  to join the AskBio Scientist II, Nanoplatform discovery R&D team and be part of our continued success! Position Overview  The Scientist II, Nanoplatform Discovery R&D, reporting to the Director, Non-Viral Delivery, will engage in non-viral delivery R&D in support of our in vivo therapeutic gene therapy and gene editing preclinical programs in rare, inherited disease through leading and/or executing experimental studies that characterize and optimize LNP candidates and contribute to lead formulation selection/optimization. The ideal candidate should have experience with non-viral delivery systems for DNA/RNA cargos, with significant experience in lipid chemistry, LNP formulation, characterization and optimization and possess the qualities of an innovative and enthusiastic team player, problem solver with excellent communication skills. The position is based at AskBio’s RTP, NC Headquarters Facility. Responsibilities Design, develop, test, and optimize novel LNP systems, establish libraries for lead formulation screening/identification/optimization Help non-viral delivery team identifying novel lipids, lipid modifications, conjugations approaches, new formulation and targeting processes. Improve existing LNP formulations, working with internal teammates and external collaborators/partners for validating the receipts/protocols and establishing

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  • Research Associate, Formulation

    The Formulation Research Associate, reports to the Scientist II, Analytical Development, and is responsible for the development, qualification, and execution of analytical assays for formulation studies and stability studies. The position is based at AskBio’s RTP, NC Headquarters Facility.

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  • Research Associate II, Histologist (Translational Medicine)

    The Research Associate II, Histotechnologist (Translational Medicine), reporting to Director, Pathology will be responsible for production of high-quality slide staining, microscope slide scanning, and image analysis to detect RNA and protein in cells including procedures employed by our lab include preservation of cells or tissues (e.g. fixation in PFA, NBF, or freezing following sucrose gradient), tissue trimming, tissue processing [with autoprocessor], block labeling (autolabeler), paraffin embedding or frozen mount whole tissue or OCT embedding, slide labeling (autolabeler), microtomy (tissue sectioning) with microtome (manual or auto) or cryostat/cryomicrotome, manual or automated staining (H&E and special stains), manual or automated immunolabeling (chromogenic or fluoro), in situ hybridization with RNAscope (chromogenic or fluoro), manual or automated coverslipping, quality checks for image and slide quality, image analysis, sample storage, recordkeeping, and sample organization with tracking in laboratory information management software. This position is located at AskBio’s Headquarters in RTP, North Carolina.

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  • Associate Director, EU Regulatory Strategy

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need.  Provide an environment for employees to reach their fullest potential.  Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. We have an opportunity for a Associate Director, Regulatory Strategy (EU) to join the AskBio team and  be part of our continued success! Position Overview  The Associate Director, EU Regulatory Strategy, reporting to the Senior Director, EU Regulatory Affairs, will serve as the regulatory strategy EU lead for assigned projects and provide regulatory leadership and direction for pre-clinical, clinical regulatory strategies in EU territories for AskBio’s development gene therapy products, work as the Regulatory EU Lead closely with cross-functional Regulatory team and Global Project Team members and subject matter experts to ensure that the EU regulatory strategy is aligned with regulatory requirements and expectations and that regulatory documents are high quality and submitted in a timely manner. This position will also provide product regulatory strategy and direction to internal customers, lead/participate in agency engagement activities, and manage external CRO interactions. This is an EU-based position. Responsibilities Serve as regulatory EU lead/representative, provide regulatory guidance and interpretation to guide the product development efforts in good alignment with EU regulatory requirements and expectations. Formulate preclinical and clinical regulatory strategies for the

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  • Manager, Data Management

    The Manager, Data Management, reporting to the Director, Data Management, will be responsible for oversight of all data management activities outsourced to external suppliers and/or conducted in house, including but not limited to database design specification development, database design programming, database User Acceptance Testing (UAT) and database deployment to research sites thereby ensuring the quality and integrity of all databases used in AskBio sponsored trials. This is a US-based, remote position.

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  • Senior Clinical Trial Associate – CNS Gene Therapy

    The Senior Clinical Trial Associate – CNS Gene Therapy, reporting to the Clinical Trial Manager – CNS Gene Therapy, will be responsible for supporting the creation and maintenance of paper and/or electronic clinical trial records including the Trial Master File (TMF) with a focus on maintaining inspection readiness throughout the lifecycle of an individual clinical trial or a clinical development program. This position is an integral part of the study/trial team in assuring that all clinical trial paperwork is handled appropriately and that assigned TMFs are complete, accurate, and timely. This is a US-based, remote position.

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  • Senior Talent Acquisition Partner

    The Senior Talent Acquisition Partner, reporting to the Director, Talent Management, is responsible for the recruitment of the company’s open requisitions while continuously improving recruitment processes to provide an excellent candidate experience to both active and passive candidates. To fill positions and build a talent pipeline, this role will need to maintain strong relationships with key business leaders, hiring managers, external vendors, and candidates. In addition to full-cycle recruitment, the role will also support talent management efforts including employer branding, community relations, and university partnerships. The ideal candidate will have passion for identifying, engaging, and assessing talent in support of a high-growth company. This is a remote, US-based position.

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  • Translational Project Lead

    The Translational Project Lead, reporting Vice President, Translational Medicine, will be responsible for providing scientific guidance for specific therapy areas (CNS, Muscle Metabolism, Cardiovascular) and leadership to represent the Translational Medicine function on program teams. The ideal candidate must have expertise and the ability to support the Translational Medicine either in Bioassay, Pharmacology, Toxicology or Pathology for ~40% of their time. The position is based at AskBio’s RTP, NC Headquarters Facility.

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  • Senior Vice President, Regulatory Affairs

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need.  Provide an environment for employees to reach their fullest potential.  Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. We have an opportunity for a Senior Vice President, Regulatory Affairs to join the AskBio team and  be part of our continued success! Position Overview  The Senior Vice President, Regulatory Affairs, reporting to the Chief Medical Officer/Chief Development Officer, will lead and oversee the global regulatory process for all AskBio programs including responsibility for overall regulatory strategy, regulatory risk assessment, and regulatory interactions on behalf of AskBio. This role is both strategic and operational, requiring the ability to build and lead a word-class regulatory affairs team and provide operational excellence to both early and late-stage development programs while partnering with internal and external stakeholders to ensure quality and timely global regulatory submissions and approvals. This position can be based at AskBio’s US facilities (Durham, NC and Philadelphia, PA) or be US-based, remote. Responsibilities Provide regulatory guidance, direction, and leadership on corporate regulatory strategies and execution for all the development programs. Make strategic contributions to the development and implementation of product development plans and partner with Translational Medicine, Clinical Development, Clinical Operations, Portfolio and Project Management, and CMC functions

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  • IT Program Manager

    The IT Program Manager, reporting to the Vice President, Information Technology, will create and maintain the overall project plans and timelines for the implementation programs assigned. Partner with business leaders and functional experts to provide leadership, direction, and execution of all Program Management procedures and activities from project initiation to go-live. Provide operational management to the program team, including facilitating issue identification and resolution, problem-solving, and contingency planning. Define the program’s scope and objectives, and effectively coordinate the activities of the cross-functional team to meet the objectives. Collaborate with the program team to develop and communicate program updates to key stakeholders and leadership team. This position is a US-based, remote position.

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  • Research Associate I, AAV Biology

    The Research Associate, AAV Biology, reporting to the Scientist, will conduct experimental bench work in support of development of AAV based Gene Therapy clinical candidate vectors as part of the R&D department. The ideal candidate will have direct experience with quantitative molecular biology techniques, including plasmid cloning, isolation of DNA, RNA, and protein from cells and tissues, quantitative PCR, RT-PCR, ELISA, SDS-PAGE, and Western Blot. The location of this position is RTP (Durham), North Carolina.

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  • Scientist II, Flow Cytometry & Biomarker Data Analyst

    The Scientist II, Flow Cytometry & Biomarker Data Analyst, reporting to the Scientist III, Immunology, is one of the key laboratory members who will have an opportunity to contribute to the understanding of AAV Immunogenicity by performing analyses on high-dimensional immunological assays in support of our gene therapy programs. This is an excellent opportunity for a candidate who is looking to build-up on his/ her experience in Cell Biology and Immunology lab skills by being involved in the assessment of clinical samples and drive exploratory data analyses of clinical studies to advance programs to clinical trial stages. This position could be located at our Philadelphia or RTP sites or be remote.

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  • Manager, Computer System Validation Engineering

    The Manager, Computer System Validation Engineering, reporting to the Associate Director, Computer System Validation Engineering, will be responsible for managing the computer system validation process, maintaining validated state of all GxP systems, comply with GxP and Security policies, develop and maintain department procedures, and contribute to overall IT & CSV planning and management. The ideal candidate will have excellent organization, prioritization, and communication skills and be able to work effectively both independently and in a group/collaboratively. The Manager should also be an effective leader in alignment with AskBio Values. The Manager is expected to utilize good judgment and innovative ideas to achieve a solution within standard practices and procedures.

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  • Manager, Business Development – Commercial (Viralgen Vector Core)

    The Manager, Business Development – Commercial (Viralgen Vector Core) is responsible for driving sales growth and overall commercial success of Viralgen Vector Core, working closely with the management team of Viralgen including the CEO, CSO and PMO team. This position will set and execute the go-to-market strategy and manages the commercial process of selling AAV manufacturing services to AAV developers. This role is a US-based, remote position. 

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  • Manager, Business Development – TAAV Manufacturing Solutions

    The Manager, Business Development – TAAV Manufacturing Solutions will be responsible for driving sales growth and overall commercial success. This position will work closely with the management team of the Joint Venture, the Business Development Representative executes the go-to-market strategy and manages the commercial process of selling dbDNA products and services to AAV developers. This is a US-based, remote position.

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  • Research Associate I, Bioanalytical & Bioassay

    The Research Associate I, Bioanalytical and Bioassay, reporting to the Sr. Director, Bioanalytical & Bioassay is responsible for assisting with bioanalytical and bioassay development and contributing to the technical excellence within the team. The ideal candidate must have demonstrated experience with mammalian cell culture and maintenance. This position is located at AskBio’s Headquarters in RTP, NC. 

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  • Senior Vice President, Global Manufacturing Operations

    The Senior Vice President, Global Manufacturing Operations, reporting to the Chief Technology Officer, will be responsible for overseeing and leading the manufacturing operations function to ensure the company is prepared to transition its programs from clinical manufacturing to commercial manufacturing. This position will be responsible for providing strategic direction and growth of the company necessary to achieve regulatory approval and commercial manufacture of many gene therapy programs in AskBio’s pipeline. The ideal candidate will be able to provide oversight for manufacturing of complex biologic and synthetic manufacturing systems and ensure that all systems and processes are validated and consistent with regulatory requirements. This role can be located in RTP, North Carolina, Philadelphia, Pennsylvania, and Boston, Massachusetts.  Occasional domestic and international travel may be required.

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  • Research Associate II, Immunoassay Development

    The Research Associate II, Histotechnologist, Product Development, reporting to the Scientist II, Histotechnologist, will conduct experimental bench work in support of development of rAAV Gene Therapy clinical candidate vectors. The ideal candidate will have direct experience with histological analysis of tissues, including preparing frozen tissues, cryosection, H&E and PAS staining, immunofluorescence /immunohistochemistry and RNAscope. This position is located at AskBio’s Headquarters in RTP, North Carolina.

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  • Laboratory Manager, Philadelphia Facility

    The Laboratory Manager, Philadelphia Facility, is a part-time, 30 hours/week, reporting to Vice President, Immunology will be responsible for supporting the lab facility including procurement, vendor negotiation, vendor negotiation, inventory management, logistical operations, lab design/installation and shipping of biological samples for the Philadelphia laboratories. The idea candidate must have 15+ years experience in directing and supporting genetic engineering/gene therapy labs. The location of this position is Philadelphia, PA.

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  • Research Associate II, Biodistribution

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need.  Provide an environment for employees to reach their fullest potential.  Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through. We have an opportunity for a Research Associate II, Biodistribution to join the AskBio team in Philadelphia, PA and be part of our continued success! Position Overview  The Research Associate II, Biodistribution Core, reporting Scientist II, Product Development, conducts experimental bench work in support of AskBio’s Product Development team, whose role is to design and optimize recombinant-AAV vectors for use in clinical gene therapy trials. The primary responsibility of the Biodistribution Core is to serve as the central entity for tissue management across all in vivo studies and to process a wide array of samples using cutting edge techniques for Product Development programs. Analytical strategies will be used to make both quantitative and qualitative assessments in relation to vector transduction, efficacy, distribution, toxicity, etc. The ideal candidate will have direct experience with in vivo tissue handling, nucleic acid extraction, droplet digital PCR, and next generation sequencing. The location of this position is Philadelphia, PA. Responsibilities Assist with the design, planning, and performance of experiments to analyze protein, RNA, and DNA from tissues. Sample management of multiple interdisciplinary studies. Implement

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  • Manager, Payroll (WorkDay)

    The Manager, Payroll (WorkDay), reporting to the Sr. Director, People Operations, will be responsible for the oversight of processing and preparing the US payroll through Workday, preparing the necessary journal entries, monthly reconciliations, monthly/quarterly reports, and other reports/analysis pertaining to payroll and retirement plan administration. In addition, this position is responsible for 401(k) integration maintenance and will manage relationships with downstream vendors. The ideal candidate will have excellent organization, prioritization and communication skills and partner well with the AskBio HR function and must have prior Workday experience. This is a US-based, remote position.

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  • LIMS Developer

    The LIMS Developer, reporting to the Director, Application Administration, will be responsible for the implementation and support of LIMS and ELN applications utilized across AskBio sites while following company policies and maintaining GxP regulatory compliance. This role will be the primary contact for LIMS and work with scientific stakeholders to understand current lab procedures, define requirements and support the implementation of LIMS within the laboratory environment. In addition, this position will be responsible for building a strong collaborative environment across scientific groups, system vendors and Information Technology. This position is based at AskBio’s Headquarter’s in RTP, NC.

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  • Vice President, Communication

    The Vice President, Communication is responsible for the leadership, oversight and execution of internal and external communications. This role will serve as a functional leader, line manager and subject matter expert for the AskBio’s Communications team, reporting directly to the Chief Human Resources Officer and serving as a member of several internal culture committees and DEI Council. With extensive industry knowledge and experience and outstanding leadership qualities, the VP will proactively seek to improve the efficiency, effectiveness, and quality of AskBio’s communication activities. This role is located at AskBio’s headquarters in Research Triangle Park (Durham), NC with up to 25% domestic and international travel.

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  • Research Associate II, Histotechnologist (Product Development)

    The Research Associate II, Histotechnologist, Product Development, reporting to the Scientist II, Histotechnologist, will conduct experimental bench work in support of development of rAAV Gene Therapy clinical candidate vectors. The ideal candidate will have direct experience with histological analysis of tissues, including preparing frozen tissues, cryosection, H&E and PAS staining, immunofluorescence /immunohistochemistry and RNAscope. This position is located at AskBio’s Headquarters in RTP, North Carolina.

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  • Research Associate II, In-Vivo (Product Development)

    This Research Associate II, In-Vivo will report to the Senior Scientist, Group Lead for In-Vivo Biology (IVB) and conduct experimental bench work and provide technical expertise in the development of rAAV gene therapy clinical candidate vectors. This position is expected to contribute to the function of the IVB team, which has responsibility for executing in vivo work related to rAAV vector evaluation and development and characterization of the animal disease models and contributes to the delivery of the lead and back-up clinical candidate vectors for various indications. with therapeutic strategies that may include gene replacement, gene knock down, gene modulation and combinations of those approaches. The ideal candidate should be well versed in tail vein injections, orbital vein injections, hydrodynamic injections, temporal vein injections, colony breeding, necropsies, blood and tissue collection and processing. The location of this position is in Durham (RTP), North Carolina. 

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  • Research Associate III, Upstream Process Development

    The Research Associate III, UPD  at AskBio will report to the Sr. Scientist/Scientist, Upstream Process Development, will contribute towards the development upstream (cell culture) processes for production of recombinant Adeno-associated viral (rAAV) vector gene therapies. This position will work on upstream process development, scale-up, optimization, characterization, and transfer of projects. This position is based in AskBio’s Headquarters facility in RTP, NC.

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Equal Opportunity Employer

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements.

If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email.