Careers in Gene Therapy

Let’s make history together

AskBio is a world-leading gene therapy company with unrivaled technology and a promising therapeutic pipeline, making us an exciting place full of promise, discovery and advancement. We are a fast-growing, patient-focused team that embraces collaboration, creative thinking and groundbreaking science to change lives.

Our headquarters are in Research Triangle Park, North Carolina, with European offices and facilities in Edinburgh, Scotland, and San Sebastián, Spain.

A benefits package worthy of our mission

We come to work each­­ day for a purpose greater than the job itself. For that reason, we offer employee benefits that reflect the importance of our work and the quality and skill of our people.

  • Collaborative and inclusive culture
  • Health, dental and vision insurance
  • 401(k) plan with company match
  • Health and dependent care flexible spending account
  • Life insurance
  • Short- and long-term disability insurance
  • 4 weeks of paid time off
  • 13 paid company holidays
  • 5 days annual sick leave
  • Business casual
  • Career advancement
  • On-site gym and beautiful walking paths
  • Collaborative and inclusive culture
  • Employer Pension Scheme
  • Life insurance
  • Critical Illness Cover
  • Private Healthcare
  • 30 days paid company holidays plus bank holidays
  • Bike to work scheme
  • Business casual
  • Career advancement
  • On-site gym and beautiful walking paths

Our Values

When you live an AskLife™, you join a team that embraces meaningful values to ensure our success.

Ask Life
Authoratative

Authoritative
We bring decades of experience in discovery and gene therapy development – from the bench to the bedside – that we want to share with the world.

Confident Icon

Confident
Driven by excellence and achievement, we have an unrivaled end-to-end gene therapy platform with foundational discoveries essential to the industry.

Boundless icon

Boundless
We are not afraid of the impossible and continuously innovate to make gene therapies accessible to all those in need.

Enthusiastic Icon

Enthusiastic
We love what we do and wake up every day motivated by a much larger purpose to change lives and erase genetic disease.

Responsible Icon

Responsible
We are humbled by the enormity of our mission and its meaning to families. We hold a relentless commitment to advance science and clinical outcomes.

Browse Open Positions

Please review the following open positions and apply now to upload your resume.

  • Research Associate, AAV Biology

    The Research Associate, AAV Biology, reports to the Senior Director, Product Development and will conduct experimental bench work in support of development of rAAV Gene Therapy clinical candidate vectors as part of the Product Development team. The Product Development team has responsibility for analysis of DNA, RNA, and protein expression from tissues and cell lines, and analysis of samples across many disease indications, including CNS, neuromuscular, liver systemic and liver metabolic rare diseases. The therapeutic strategies may include gene replacement, gene knock down, gene modulation, and combinations of those approaches. The ideal candidate will have direct experience with quantitative molecular biology techniques, including isolation of DNA, RNA, and protein from cells and tissues, quantitative PCR, RT PCR, ddPCR, ELISA, SDS_PAGE, and Western Blot.

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  • Senior Human Resources Business Partner (HRBP)

    The Senior Human Resources Business Partner (HRBP), reporting to the Chief Human Resources Officer, will consult, advise, coach and partner with leadership on people and organizational needs, ensuring alignment with the company and HR objectives. This position will influence the overall people strategy and ensure effective execution of HR solutions to achieve desired business results. A successful candidate will have extensive and progressive HR Generalist experience within multiple HR disciplines, in-depth knowledge of HR practices and prior experience managing complex employee relations issues. This position will be based in the RTP, NC Headquarters.

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  • Executive Assistant, R&D

    The Executive Assistant, R&D will provide direct administrative support to our Chief Scientific Officer and Vice President, R&D, in addition to the R&D team located at our RTP, NC Headquarters. This position will ensure the needs of the executives and the department are prioritized, organized, and executed to maximize productivity. On a day-to-day basis, this position can expect to handle calendar management, expense reports, document creation, development of presentations, tracking/processing of purchasing requests (proposals, POs, accruals), travel arrangements and other departmental support tasks, as assigned.

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  • Research Associate, Formulation

    The Research Associate, Formulation will be responsible to support the development, qualification and execution of analytical assays for formulation studies and stability studies. 

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  • Research Associate, Formulation & Analytical Development

    The Research Associate, Formulation and Analytical Development will be responsible to support the development, qualification and execution of analytical assays for formulation studies and stability studies. This position will provide analytical test methods development, qualification, and validation support for future non-GMP drug product release.

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  • Associate Director, Program Management

    The Associate Director, Program Management (CNS) will report to the Vice President, Portfolio & Program Management and will be responsible for the creation and maintenance of the overall development plans and timelines for the drug development programs assigned. This position will partner with Program Lead to provide leadership, direction, and execution of all Program Management procedures and activities from pre-clinical through product launch including providing operational management to the program team, including facilitating issue identification and resolution, problem-solving, and contingency planning. In collaboration with key stakeholders, this position will define the program’s scope and objectives, and effectively coordinate the activities of the cross-functional team to meet the objectives. The ideal candidate will be able to effectively collaborate with the program team to develop and communicate program updates to key stakeholders and leadership team in a timely manner. 

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  • Associate Director, Program Management (CNS)

    The Associate Director, Program Management (CNS) will report to the Vice President, Portfolio & Program Management and will be responsible for the creation and maintenance of the overall development plans and timelines for the drug development programs assigned. This position will partner with Program Lead to provide leadership, direction, and execution of all Program Management procedures and activities from pre-clinical through product launch including providing operational management to the program team, including facilitating issue identification and resolution, problem-solving, and contingency planning. In collaboration with key stakeholders, this position will define the program’s scope and objectives, and effectively coordinate the activities of the cross-functional team to meet the objectives. The ideal candidate will be able to effectively collaborate with the program team to develop and communicate program updates to key stakeholders and leadership team in a timely manner. 

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  • Senior Director, Medical Affairs – Neuromuscular

    The Senior Director, Medical Affairs – Neuromuscular, reporting to the Vice President, Medical Affairs, will be responsible for development and delivery of the Neuromuscular Medical Affairs strategies for AskBio’s Neuromuscular clinical development and pipeline programs. This is a US-based, remote position with the ability to travel to meetings and conferences up to 35% of the time, post-pandemic.

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  • Senior Director, Medical Affairs – CNS

    The Senior Director, Medical Affairs – CNS, reporting to the Vice President, Medical Affairs, will be responsible for development and delivery of the CNS Medical Affairs strategies for AskBio’s CNS clinical development and pipeline programs. This is a US-based, remote position with the ability to travel to meetings and conferences up to 35% of the time, post-pandemic.

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  • Director, Manufacturing

    The Director, Manufacturing is a critical member of the Process Development & Manufacturing team in AskBio CMC and will oversee routine upstream cell culture and rAAV viral vector production and downstream purification operations to support the AskBio’s early research and development programs as well as provide CMC support for GLP and GMP manufacturing at Viralgen Vector Core. This individual will lead a team of scientists and associates to manufacture and characterize high quality recombinant AAV vectors in a highly interdisciplinary environment and be expected to communicate effectively and productively with the research & development organization, early stage upstream and downstream PD group, regulatory CMC group and other cross-functional organizations such as preclinical, clinical, and translational sciences groups as needed to ensure the product quality expectations are achieved.

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  • Senior Talent Acquisition Partner

    The Senior Talent Acquisition Partner, reporting to the Director, Talent Management, is responsible for the recruitment of the company’s open requisitions while continuously improving recruitment processes to provide an excellent candidate experience to both active and passive candidates. To fill positions and build a talent pipeline, this role will need to maintain strong relationships with key business leaders, hiring managers, external vendors, and candidates. In addition to full-cycle recruitment, the role will also support talent management efforts including employer branding, community relations, university partnerships and an internship program.

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  • Manager, Clinical Supplies

    The Manager, Clinical Supplies will provide strategic oversight of the end-to-end supply chain for assigned gene therapy investigational assets, including provision of placebo supplies, as needed, based on study design and implements supply strategies to deliver investigational medicines to patients. This position is responsible for influencing clinical plans relative to investigational product (IP) supply and optimizing supply strategies, so they are patient-focused, risk-adjusted, and cost effective. Furthermore, the CSM will follow through on supply chain performance to ensure successful execution of the supply chain, with a focus on quality. This role involves oversight of AskBio sponsored clinical studies (all phases).

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  • Director, Medical Writing

    The Director, Medical Writing will be responsible for the overall scientific leadership providing clinical direction to team members, developing and writing content for their specific projects as well as reviewing scientific content created outside AskBio. This position will have direct interaction with leading key opinion leaders. The Medical Writer is required to travel to project specific advisory board meetings, and at times, may be required to attend scientific congresses. Projects may include development of clinical content which includes case studies, text based and power point slides. The ideal candidate must be knowledgeable on the appropriate guidelines including, but not limited, to the ACCME Standards for Commercial Support, PhRMA Code, and OIG Guidance.

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  • Scientist, Gene Editing

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We are seeking a highly motivated Scientist, Gene Editing to join our growing R&D team. The successful candidate will support our discovery efforts, as well as preclinical and clinical AAV gene therapy programs. The ideal candidate has in depth knowledge of CRISPR gene editing and gene modulation, DNA repair pathways, cell engineering, genomics platforms and recombinant AAV therapeutics. He/she can lead research teams and execute experimental studies that characterize and optimize therapeutic gene editing candidates through early development to first-in-human testing. We are excited about our next Scientist, Gene Editing to join the AskBio team! Job Responsibilities The Scientist, Gene Editing will: Lead and execute gene editing and gene therapy projects, and assays to support in vitro/in vivo proof of concept and safety outcomes. Use relevant rodent or non-human primate models to test hypothesis and characterize gene editing/therapy candidates in development. Lead and support internal and cross-functional research teams, to increase team capabilities and address strategic needs. Lead and support collaborations with academic and/or industry partners to meet stage gated/milestone-driven goals for early therapeutic R&D programs. Take initiative to identify and support emerging technical approaches and platforms that may drive increased value for pipeline programs. Assist with the preparation and review of protocols, clinical study reports and translational medicine sections of plans, INDs, manuscripts, and technical reports. Train or work closely with other lab-based personnel within R&D, translational medicine, and product development to ensure optimal laboratory environment (collaboration, culture, safety) Demonstrate initiative, teamwork, collaboration, and technical expertise as an independent and team player. Follow best practices for data integrity complying with organization and company standard operating procedures in a timely fashion. Required Education & Experience PhD in molecular biology, cell biology or related discipline with 6 years of experience in postdoc or industry setting. Expertise in human/murine preclinical disease models and related experimental work. Prior experience in a BSL2 or more environment. Broad experience with gene editing modalities and techniques, including NGS

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  • Bioanalytical and Bioassay Lead

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview We are seeking 2 experienced and highly motivated Bioanalytical and Bioassay Leads to join our Bioanalytical and Bioassay group located at Research Triangle Park, Durham NC. Reporting to the Sr. Director, the Bioanalysis and Bioassay Lead is expected to lead the bioanalytical and bioassay development and drive technical excellence within the team. We are excited about our next Bioanalysis and Bioassay Lead to join the AskBio team! Job Responsibilities The Bioanalysis and Bioassay Lead will: Serve as a SME and/or lead scientist, lead and manage the internal and external bioanalytical and bioassay assay design, development, troubleshooting, transferring, and sample testing and reporting to support preclinical and clinical gene therapy program development. Independently develop, optimize, and troubleshoot Cell-based assays as well as other plate-based assays using variety of platforms including colorimetric/luminescent/fluorescent ELISA, MSD, and high-content imaging in support of developing release and characterization assays for gene therapy products. Independently develop, optimize, and troubleshoot molecular biology/biochemistry assays, such as ELISAs, MSD, enzyme activity assay, qPCR/ddPCR to meet the bioanalytical need for various AAV gene therapy programs. Prepare/scientific review of analytical data and methods, protocols, and reports generated by internal and external laboratories. Participate and present in departmental and cross-functional project team meetings. Author and review relevant sections of regulatory submissions support the IND/CTA and BLA/MAA submissions. Manage CRO relationships for assay validation and qualification. Stay current with the latest bioanalytical and bioassay methods and technologies, current regulatory regulation and guidance, and industry’s best practices. Required Education & Experience Ph.D. in Biology, Biochemistry, molecular biology, Cell Biology, or a related field with minimum 6+ years of relevant experience and a strong publication record in peer reviewed journals or Master with 12+ years of directly related industry experience. Experience and expertise in virus-related research including cell culture, virus transduction, cell line development, and characterization. Highly experienced in experiment designing, executing, and troubleshooting for qPCR/RT-qPCR, ddPCR/RT-ddPCR, ELISA, MSD, cell-based assay, and ligand-based assays FACS, or other novel platforms. Previous supervisory experience in bioanalytical or cell-based

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  • Director, Business Development

    About AskBio Asklepios BioPharmaceutical, Inc. (AskBio), a wholly owned and independently operated subsidiary of Bayer AG acquired in 2020, is a fully integrated AAV gene therapy company dedicated to developing life-saving medicines that have the potential to cure genetic diseases. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes therapeutics for Pompe disease, Parkinson’s disease and congestive heart failure, as well as out-licensed clinical indications for hemophilia and Duchenne muscular dystrophy. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. Founded in 2001 and an early innovator in the gene therapy field, the company holds more than 850 patents in areas such as AAV production and chimeric and self-complementary capsids. Learn more at www.askbio.com. Position Overview The Director, Business Development is an engaged, experienced, and inspirational biopharmaceutical industry professional who will help position the Company as a leader in the emerging field of gene therapy. Reporting to the General Counsel, and in partnership with the Executive Team, the Director, Business Development will play a lead role in developing and executing the near term and long-range strategy for the Company at the interface of science, medicine, and business. Direct responsibilities will include business development strategy and execution, including licenses, collaborations and acquisitions. Keen insights in these areas will help the Company position existing programs in this rapidly evolving gene therapy market and identify opportunities to expand its pipeline and product portfolio. The Director, Business Development will bring cross-functional leadership and collaboration to ensure alignment, ideation, and implementation, working closely with the Company executive leadership team, in a nimble and fast-moving environment. Demonstrating leadership as it relates to the Company’s culture and values are paramount for this role. He/she will also serve as a leader with external constituents including thought leaders, partners, and as a general representative of the Company. We are excited about our next Director, Business Development to join the AskBio team! Job Responsibilities Lead the development, implementation, and execution of overall company business development strategy focused on optimizing key value drivers across the organization while fully complimenting corporate strategy set by CEO. Lead the development, implementation, and execution of overall company business development strategy focused on optimizing key value drivers across the organization while fully complimenting corporate strategy set by CEO. Lead sourcing, due diligence, negotiations and execution of licenses, collaborations, sponsored research and acquisitions or divestitures. Lead global, cross-functional team on a project-by-project basis. Serve as a role model in establishing a collaborative spirit within the BD organization. As the Company continues to evolve, play a leadership role in supporting cultural transitions associated with product development and pipeline strategies in early clinical research through clinical developments stages, while maintaining a strong

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  • Scientist I/II, Gene Editing

    We are seeking a highly motivated scientist to join our growing R&D team. The successful candidate will support our preclinical in vivo gene editing programs in Research and Development.

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  • Research Associate, In Vivo

    This position will report to the Group Leader for in vivo biology (IVB) and conduct experimental bench work and provide technical expertise in the development of rAAV gene therapy clinical candidate vectors.

    The Research Associate is expected to contribute to the function of the in vivo biology (comparative medicine) team. IVB has responsibility for executing in vivo work related to rAAV vector evaluation and development and characterization of the animal disease models. IVB contributes to the delivery of the lead and back-up clinical candidate vectors for various indications. Areas of interest to AskBio include CNS, neuromuscular, liver systemic and liver metabolic rare diseases. Therapeutic strategies may include gene replacement, gene knock down, gene modulation and combinations of those approaches.

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Equal Opportunity Employer

Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements.

If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561-6210 or sending us an email.