Scientific thought-leaders

Below are select papers that have been published and authored by AskBio team members and other leaders in the field. AskBio team members have hundreds of research papers that have been published by the NIH and major scientific journals.

Read our FAQs or contact us if you have questions or are interested in a research collaboration. 

Research Publications

Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector
Joshua C Grieger, Stephen M Soltys, and Richard Jude Samulski
October 06, 2015

Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective
Eric Hastie and R. Jude Samulski
March 23, 2015

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes
R. Jude Samulski and Nicholas Muzyczka
November 2014

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates
S J Gray, S Nagabhushan Kalburgi, T J McCown & R Jude Samulski 
April 04, 2013

Chapter twelve – Adeno-Associated Virus Vectorology, Manufacturing, and Clinical Applications
Joshua C. Grieger, Richard J. Samulski
February 03, 2012

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors
Steven J. Gray, Stacey B. Foti, Joel W. Schwartz, Lavanya Bachaboina, Bonnie Taylor-Blake, Jennifer Coleman, Michael D. Ehlers, Mark J. Zylka, Thomas J. McCown, and R. Jude Samulski
April 08, 2011

Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery
Brooke R. Snyder, Steven J. Gray, Eric T. Quach, Jeremiah W. Huang, Cary H. Leung, R. Jude Samulski, Nicholas M. Boulis, and Thais Federici
March 28, 2011

Selective and Rapid Uptake of Adeno-Associated Virus Type 2 in Brain
Jeffrey S. Bartlett, R. Jude Samulski, and Thomas J. McCown
March 20, 2008

Ocular Gene Transfer with Self-Complementary AAV Vectors
Katsutoshi Yokoi; Shu Kachi; H. Steve Zhang; Philip D. Gregory; S. Kaye Spratt; R. Jude Samulski; Peter A. Campochiaro
July 2007

Separate Basic Region Motifs within the Adeno-Associated Virus Capsid Proteins Are Essential for Infectivity and Assembly
Joshua C. Grieger, Stephen Snowdy, Richard J. Samulski
March 03, 2006

Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy
ZhijianWu, AravindAsokan, R. JudeSamulski
May 17, 2006

AAV Hybrid Serotypes: Improved Vectors for Gene Delivery
Choi, Vivian W.; McCarty, Douglas M.; Samulski, R. J.
November 03, 2005

Packaging Capacity of Adeno-Associated Virus Serotypes: Impact of Larger Genomes on Infectivity and Postentry Steps
Joshua C. Grieger, Richard J. Samulski
February 08, 2005

Effects of Adeno-Associated Virus DNA Hairpin Structure on Recombination
Vivian W. Choi, R. Jude Samulski, Douglas M. McCarty
December 28, 2004

Cross-Dressing the Virion: the Transcapsidation of Adeno-Associated Virus Serotypes Functionally Defines Subgroups
Joseph E. Rabinowitz, Dawn E. Bowles, Susan M. Faust, Julie G. Ledford, Scott E. Cunningham, R. Jude Samulski
January 06, 2004

Development and Characterization of Novel Empty Adenovirus Capsids and Their Impact on Cellular Gene Expression
Jackie L. Stilwell, Douglas M. McCarty, Atsuko Negishi, Richard Superfine, R. Jude Samulski
September 5, 2003

Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
Joseph E. Rabinowitz, Fabienne Rolling, Chengwen Li, Hervè Conrath, Weidong Xiao, Xiao Xiao, R. Jude Samulski
October 9, 2001

Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors
Jeffrey S. Bartlett, Rose Wilcher, R. Jude Samulski
December 16, 1999

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus
Xiao Xiao, Juan Li, Richard Jude Samulski
November 24, 1997