Creating a paradigm shift in raw materials

Synthetic biology based on natural genomic knowledge has wide-ranging potential to advance how we bring more effective and safer therapeutics to patients.  It allows us to treat more patients by speeding production and lowering cost.

Enzymatic DNA does not require larger fermentation volumes of plasmids. This means we can generate DNA with no bacterial impact that can be produced in higher volumes in significantly less time than plasmid DNA. More importantly, we can assemble safer DNA sequences at a larger scale with the same therapeutic effect of natural synthesized DNA. 

Working collaboratively with TAAV Biomanufacturing Solutions, AskBio is advancing neDNA™* into clinical applications with extensive development and manufacturing capabilities.

*Touchlight™, proTL™, dbDNA™, doggybone™and doggyboneDNA™ are all trademarks of Touchlight Genetics Limited.

Technology for making dbDNA™, a trademark of Touchlight Genetics Ltd., is licensed from Touchlight IP Ltd.

We believe that neDNA™ will offer an improved safety profile versus plasmid DNA for the manufacture of recombinant adeno-associated virus (rAAV) gene therapy vectors.  The TAAV manufacturing process consistently produces large amounts of neDNA using technology licensed from Touchlight IP Ltd.* in reduced times, which can be measured in days versus the months that are typical when producing plasmid DNA. neDNA features a novel, minimal linear double-stranded DNA vector. It’s closed ends improve expression characteristics. It is capable of long and difficult sequences and eliminates bacterial sequences.

neDNA™ for better AAV therapeutics

Doggybone™ DNA for better AAV therapeutics
Doggybone™ DNA for better AAV therapeutics

TAAV’s process for producing neDNA

dbDNA process Circular DNA Template
Circular DNA Template
slide 2 Denature
slide 3 029 DNA polymerase and primer
slide4 Rolling circle amplification of DNA template
slide 5 strand displacement
slide 6 Protelomerase binds, cuts and ligates
GMP manufacturing

Clinical and commercial GMP manufacturing

Our extensive manufacturing facilities in San Sebastian, Spain, allow for high-yield output of AAV vectors for any serotype and for the production of neDNA™, a benchtop alternative to plasmid DNA.

Advance AAV production »

Research and collaborations Lab Worker

Research and collaborations

Being a leader means collaborating with visionaries in the research communities to accelerate access and lower the cost of life-changing genetic medicine.

Our research collaborations »