Congestive Heart Failure

Congestive heart failure (CHF) is a condition in which the heart is unable to supply sufficient blood and oxygen to the body and can result from conditions that weaken the heart muscle, cause stiffening of the heart muscles, or increase oxygen demand by the body tissues beyond the heart’s capability.

Heart disease is the leading cause of death worldwide, with CHF affecting an estimated 1% of the Western world, including over five million Americans. There is no cure, and medications and surgical treatments seek to relieve symptoms and slow further damage.

Research, however, suggests that protein I-1 is downregulated in failing hearts. Gene therapy to express a constitutively active form of the protein I-1 (I-1c) may provide a new approach to treating CHF.

Visit the National Institute of Health’s National Heart Blood and Lung Institute to learn more about Congestive Heart Failure.

CHF Advocacy Partners

We are fortunate to work with patient advocacy groups, as well as leading researchers, scientists and medical professionals to bring new therapeutics for CHF into the clinic.

Clinical Trials

Many who can benefit from promising gene therapeutics face a significantly altered way of life. Many of these diseases are progressive. Thus, time is of the essence and the importance of every clinical trial has greater meaning to all of us at AskBio.

If you’re interested in getting more information on clinical trials for any of the diseases we have in our pipeline, all you have to do is Ask.